5 ESSENTIAL ELEMENTS FOR METHADONE PRESCRIPTION

[sixty one] Like several other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with distinctive potency. Dextromethadone, that's less potent being an opioid, is a lot more powerful at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone features a lower affinity, with a